A new study from the University of Chicago1 comparing the effects of estrogen and retinoic acid on breast cancer cell genes shows that they have inverse effects- estrogen tips the scales towards cell proliferation and retinoic acid inhibits cellular growth.
The findings, reported in the June 25, 2009, issue of the journal Cell, may lead researchers to a whole new set of drug targets for breast cancer. The most widespread forms of breast cancer are driven by the female estrogen hormone. Estrogen and retinoic acid modify the expression of many of the same genes, and this control of gene expression regulates basic cellular processes, say the report’s authors. When regulation is unbalanced, it can lead to cancer.